https://www.selleckchem.com/products/r428.html
Pathologically, there is severe amyloid deposition in the leptomeninges and cerebral amyloid angiopathy of leptomeningeal and penetrating vessels. These amyloid aggregates are formed mostly by CSF produced TTR and seem resistant to the available ATTRv therapies that increase the stability or reduce the production of plasma TTR. This indicates that CNS involvement will become a meaningful issue in patient management in upcoming years. Synaptic damage has been proposed to play a major role in the pathophysiology of Huntington's disease (HD),
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