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After treatment, the SAS scores, KI scores and serum levels of FSH in the two groups and the scores of agitated and depressive symptom in the acupuncture group were lower than those before treatment ( 0.05), and the acupuncture group was lower than the western medication group ( 0.05). Regulating menstruation and promoting pregnancy acupuncture therapy can effectively improve the negative emotions of patients with POI and reduce serum level of FSH . Regulating menstruation and promoting pregnancy acupuncture therapy can effective