https://pd173074inhibitor.com/....fv-429-causes-autoph
Herein, employing site-directed mutagenesis, allelic change, quantitative PCR analyses, immunoblotting and 13C-heme uptake experiments, we delineated the differential efforts associated with the extracellular FRAP/PNPNL loop residue His-624 in HasR as well as His-221 in its N-terminal plug domain required for heme capture to heme transport and signaling, respectively. Particularly, we show that substitution of the N-terminal connect His-221 disrupts both signaling and transport,
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