https://www.selleckchem.com/pr....oducts/ifenprodil-ta
Mechanistic investigations showed that continual radiation activates the NF-κB signalling cascade and promotes nuclear translocation of p65, leading to enhanced expression of YY1, the transcription factor that directly suppresses miR-103a transcription. Restoring miR-103a expression under these conditions suppressed the FGF2-XRCC3 axis and decreased the radioresistance capability. Moreover, Tf-NPs improved radiosensitivity and provided a significant survival benefit. We suggest that the NF-κB-YY1-miR-103a regulatory axis is
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