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We now have previously shown that β2AR agonism produces intracellular ROS, an effect that's needed is for receptor function, and which post-translationally oxidizes β2AR cysteine thiols to Cys-S-sulfenic acids (Cys-S-OH). Also, highly oxidative conditions can irreversibly oxidize Cys-S-OH to Cys-S-sulfinic (Cys-SO2H) or S-sulfonic (Cys-SO3H) acids, that are incapable of additional participating in homeostatic redox reactions (for example., redox-deficient). The purpose of
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