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AIMS SGLT2 inhibitors being recommended as an adjunct to insulin treatment for glycemic control in kind 1 diabetes (T1D) patients. Nonetheless, issue was raised due to an increase in renin-angiotensin-system (RAS) activity reported in a clinical trial for which an SGLT2 inhibitor had been included while insulin dose ended up being reduced in T1D patients. We formerly stated that insulin inhibits intrarenal angiotensinogen (Agt) gene transcription and RAS activation. We hypothesized that insulin, rathe

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