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When Stanley Falkow introduced Molecular Koch's Postulates (Falkow, 1988) as a conceptual framework to spot microbial factors that contributed to infection, he reaffirmed the prominent part that the basic concepts of hereditary evaluation should play in defining genotype-phenotype associations in microbial pathogens. In ancient bacterial genetics the nature of mutations is inferred through cis-trans complementation and by indirectly mapping their relative place and real distance through rec

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