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After exposure of the sheep parietal pleura to 240 mOsm/kg (hyposmolar) the transmesothelial resistance (R ) significantly increased (p 0.05) while at 340 mOsm/kg (hyperosmolar) the R was not significantly altered. PEs osmolality differs depending on the underlying pathology and is linked to PE pH and glucose. Hypo-osmotic PEs can lead to decreased pleural permeability. These results warrant further study of the PEs osmolality levels on the function of the pleural mesothelial cells. PEs osmolality differs depending on the underlying
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