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Vaccines are critical cost-effective tools to control the COVID-19 pandemic. However, the emergence of SARS-CoV-2 variants may threaten the global impact of mass vaccination campaigns. The objective of this study was to provide an up-to-date comparative analysis of the characteristics, adverse events, efficacy, effectiveness and impact of the variants of concern for nineteen COVID-19 vaccines. References for this review were identified through searches of PubMed, Google Scholar, BioRxiv, MedRxiv, regulatory drug agencies and pharmaceutic