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© 2020 The Authors. Orthopaedic Surgery published by Chinese Orthopaedic Association and John Wiley Sons Australian Continent, Ltd.almost all of existing nanomedicines tend to be administrated intravenously to favour cyst accumulation via improved permeability and retention (EPR) result, which, however, is affected with lots of downsides such as reduced drug bioavailability and severe side effects. Impressed through the improvements in nutriology, in this work,