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PURPOSE The surface-matching registration method in the current neuronavigation completes the coarse registration mainly by manually selecting anatomical landmarks, which increases the registration time, makes the automatic registration impossible and sometimes results in mismatch. It may be more practical to use a fast, accurate and automatic spatial registration method for the patient-to-image registration. METHODS A coarse-to-fine spatial registration method to automatically register the patient space to the image space without placing
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