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The SERS-based platform we demonstrated can be widely applied for atomically precise control and molecular-level characterization of hydration water on various heterogeneous surfaces of biological and industrial importance.Therapies based on Toll Like Receptor agonists (TLRa) are emerging as a promising modality for cancer immunotherapy to recruit antitumor T-cells in unresponsive immunologically "cold" tumors. Often, combinations of agonists are employed to synergistically enhance efficacy. However, low efficacy and severe toxicities de

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