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In addition to computing chemical potential differences in the macroscopic limit directly from molecular dynamics simulation, the new method provides insights into the size dependency that is introduced to intensive properties in small systems.Recently, the United States Food and Drug Administration approved esketamine, the S-enantiomer of ketamine, as a fast-acting therapeutic drug for treatment-resistant depression. Although ketamine is known as an N-methyl-d-aspartate (NMDA) receptor antagonist, the underlying mechanism

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