https://hsp-signal.com/index.p....hp/foodborne-botulis
E2-bovine serum albumin (BSA), a sizable molecular membrane-impenetrable conjugate of E2, may also upregulate MMP-9 protein expression in MCF-7, plus the action of E2-BSA can be abolished by PI3K inhibitor LY294002; treating MCF-7 simultaneously with PELP1-shRNA and LY294002 did not show synergetic inhibitory impact on E2-BSA-induced MMP-9 expression. Our results indicated that estrogen-induced MMP-9 appearance in ER-positive breast cancer cells might be through PELP1-mediated PI3K/A
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