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Coculture of AGS cells with CEAE-KP at a noncytotoxic concentration of 16 μg/ml and H. pylori reduced IL-8 secretion by ~ 60% at 12 h, which was consistent with the decreased level of mRNA expression, and inhibited neutrophil chemotaxis to IL-8. sHP (100 ng/ml) induced marked monocyte chemoattraction, and this was decreased by ~ 60% by CEAE-KP. CONCLUSION CEAE-KP might serve as a potent alternative medicine to ameliorate the inflammation mediated by H. pylori infection.BACKGROUND Relaxin is an endogenous protein that has been shown to h