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veal that intratumor heterogeneity is an indicative factor for patient survival due to its impact on anti-tumor immune response. Highly heterogeneous melanoma tumors are associated with reduced immune cell infiltration and immune response activation as well as decreased survival. Our results reveal that intratumor heterogeneity is an indicative factor for patient survival due to its impact on anti-tumor immune response. Distant metastases are currently the main cause of treatment failure in locally advanced rectal cancer (LARC) patient