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The main manifestation of acute interstitial nephritis (AIN) due to immune checkpoint inhibitors is acute kidney injury. We report here a biopsy-proven AIN revealed by tubular acidosis. This case highlights that immune checkpoint inhibitor prescribers must be aware of electrolytic disorders since tubular dysfunction can precede serum creatinine increase and reveal renal toxicity. © The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.Background Membranous nephropathy (MN) represents two distinct disease entiti
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