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This study aimed to investigate the role of cytokines as intermediates in the pathway from increased adiposity to disease. BMI and circulating levels of up to 41 cytokines were measured in individuals from three Finnish cohort studies (n = 8,293). Mendelian randomization (MR) was used to assess the impact of BMI on circulating cytokines and the impact of BMI-driven cytokines on risk of obesity-related diseases. Observationally, BMI was associated with 19 cytokines. For every SD increase in BMI, causal effect estimates were strongest for h
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