https://jg98inhibitor.com/endo....some-dysregulation-i
As both apatinib and SV are metabolized primarily by cytochrome P450 variant CYP3A4, they have been very likely to interact. Therefore, the potential effect of SV co-administration on pharmacokinetics of apatinib in Sprague-Dawley male rats is demonstrated the very first time.Sixteen rats had been randomly divided in to two groups (n = 8), 2 mg/kg SV orally co-administrated for a week (group and the corresponding control team (group A). Apatinib concentrations of r
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