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Interestingly, while scattered throughout the primary sequence, these amino acids come close to each other within two domains of the folded AOx. Although the role of one or both of these regions as the PTS3 signal is not finally proven, our data indicate that the signal guiding AOx into peroxisomal matrix is not a linear sequence but a signal patch. Copyright © 2020 Kempiński, Chełstowska, Poznański, Król, Rymer, Frydzińska, Girzalsky, Skoneczna, Erdmann and Skoneczny.Inter-organelle membrane contact sites (MCSs) are classically defined
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