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preferably multicentric, are required to find the superiority of brahmi over donepezil. Sporadic Creutzfeldt Jakob Disease, the most common reported prion disease, is a fatal neurodegenerative disease caused by the misfolding of protein PrP to PrP . EEG is the first test to support the clinical diagnosis of sporadic CJD (sCJD). This study is carried out to describe the comprehensive electroencephalography changes in a cohort of patients with probable sCJD from south India. This retrospective observational study is conducted by reviewin