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Introduction Gasdermin A (GSDMA) and Gasdermin B (GSDM have been associated with childhood and to a lesser extent with adult asthma in many populations. In this study, investigate whether there is an association between GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C) at locus 17q21.2 and risk of Allergic Rhinitis among Jordanians. Also we aimed to determine if there is an association between such polymorphisms and the IgE level. Methods The study included 112 rhinitis patients and 111 Healthy controls. Gasdermin A (GSDMA) (rs7