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The B. subtilis model allowed us to identify the parasite amidotransferase as the target of lipoate analogs like 8-bromo-octanoic acid, explaining the complete loss of protein lipoylation and growth impairment caused by this compound in T. cruzi. This model could be instrumental for the screening of selective and more efficient chemotherapies against trypanosomiases.Previous studies consistently showed age-related differences in temporal judgment and temporal memory. Importantly, emotional valence plays a crucial role in older adults'