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7%) increased. In addition, ultrasound stimulation reduced the recovery time in mice with traumatic brain injury (sham 30.38 ± 1.9 min, ultrasound 7.38 ± 1.02 min, p less then 0.01). This noninvasive strategy could be used on demand to promote emergence from DOC and may be a potential treatment for such disorders.Alcohol use disorder is associated with pathophysiological changes in the dopaminergic system. Orthodenticle homeobox 2 (OTX2) is a transcription factor important for the development of dopaminergic neurons residing in the vent