https://www.selleckchem.com/pr....oducts/ap-3-a4-enobl
The maximal TGF response was smaller in HFD-fed rats than in NFD-fed rats, indicating an attenuation of TGF in HFD-induced obesity. Baseline PGC was higher in HFD-fed rats than in NFD-fed rats and was associated with higher glomerulosclerosis. We conclude that attenuated TGF and higher PGC along with hypertension in HFD-fed obese Sprague-Dawley rats could explain the higher propensity of glomerular damage observed in obesity.NEW NOTEWORTHY Reduced tubuloglomerular feedback, higher glomerular capillary pressure, and hypert