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Quorum quenching (QQ) refers to all the processes active in the disturbance of QS and it is viewed as a promising technique for dealing with microbial infection. Herein, four compounds with closely relevant substance structures to homoserine γ-lactone were synthesized and fully characterized. The substances are termed TGK-series compounds. These compounds had been subsequently tested in their QS inhibition task making use of an E. coli Top 10 QS biosensor strain, a GFP QS reporter, that probes the capabili