Mesothelioma Diagnosis A doctor can diagnose mesothelioma with a physical exam and imaging tests as well as lab work. Doctors can also conduct biopsy, which entails removing tissue and examining it under a magnifying glass. A chest X-ray, also known as a CT scan, is used to guide the needle through the lung's lining. The procedure is not invasive and can result in false negative results. Diagnosis It can take time to identify mesothelioma since it is a rare form of cancer. Your doctor will start by taking your medical history and conducting a