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The facets that determine the solubility of any provided LC in vivo are not well comprehended. We hypothesize that some of the biochemical properties of the LCs which were shown to associate with amyloid fibril development in patients also can be properly used as predictors for the amount of renal damage in an individual group that is just biased by necessary protein availability. We performed detailed biochemical and biophysical investigations of light chains removed and purified from the urine of a s