https://www.selleckchem.com/pr....oducts/epalrestat.ht
The only exception is the stability of Cu(DO2A2MnBu) which was found to be only slightly lower than that of Cu(DOTA)2- (log KCuL = 19.85 vs. 21.98). This is likely reflects exclusive coordination of the negatively charged acetate donor atoms to the Cu2+ ion forming an octahedral complex with the amides remaining uncoordinated. The only anomaly observed during the study was the rates of acid assisted dissociation of the Ln(III) complexes, which occur at a rate similar to those observed for the Ln(DOTA)- complexes. These data indicate
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