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The emergence and spread of P. falciparum parasites lacking HRP2/3 proteins and the resulting decreased utility of HRP2-based malaria rapid diagnostic tests (RDTs) prompted the World Health Organization (WHO) and other global health stakeholders to prioritize the discovery of novel diagnostic biomarkers for malaria. To address this pressing need, we adopted a dual, systematic approach by conducting a systematic review of literature for publications on diagnostic biomarkers for uncomplicated malaria and a systematic in silico analysis o