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Disease was the most important causes of calf mortality (73.2%). Among the diseases, diarrhea (63%) and respiratory disorders (17%) were the important causes of calf mortality. Malpractices in calf management were identified, including restricted colostrum and milk feeding, poor care and supplemental feeding, and poor health management. Interventions in dairy cattle health and farm husbandry are recommended to control calf mortality. Copyright © 2020 Tsegaw Fentie et al.Peroxisome proliferator-activated receptor γ (PPARγ) is a key regu