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But, once the MPPs were tested in cellular incubations with HCV replicons only Zn, Fe and free-base protoporphyrin showed comparable EC50 and IC50 values recommending that there might be critical differences in MPP uptake and intracellular access. Meso, deutero, and isohematoporphyrin derivatives, with or without material substitution, all revealed less anti-protease and antiviral tasks as compared to protoporphyrins, recommending that the planar, vinyl part stores are essential for protease active web site binding. MPPs w