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vel treatment strategies for GBM patients. We describe the clinical, mycological, immunological, and genetic characteristics of six HIV-negative patients presenting with invasive cryptococcosis. Patients with cryptococcosis without any of the classical risk factors, such as HIV infection, followed at Cayenne Hospital, were prospectively included. An immunologic and genetic assessment was performed. Five male patients and one female patient, 5 adults and one child, were investigated. All presented a neuromeningeal localization. var. and var. were isolated in
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