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More interesting is the detected chirality-anticancer relationship, where complexes Na3[Ag(S,S)-NHCR2] (R = Me, 2b; iPr, 2c) showed better anticancer activity than those of their enantiomeric derivatives Na3[Ag(R,R)-NHCR2] (R = Me, 2b'; iPr, 2c'.Engineering non-native metal active sites into proteins using canonical amino acids offers many advantages but is hampered by significant challenges. The TIM barrel protein, imidazole glycerol phosphate synthase from the hyperthermophilic organism Thermotoga maritima (tHisF), is well-suited for t

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