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047), histological grade (P = 0.039), pTN stage (P = 0.044), and WHO subtype (P less then 0.001). In addition, TLShi was a positive indicator of overall survival, as determined by Kaplan-Meier survival (P = 0.038) and multivariate Cox regression analyses (hazard ratio = 0.794, 95% CI 0.668-0.942, P = 0.008). According to the results, TLShi had a positive effect on the primary cohort patients with pTN stages II and III (P = 0.027, P = 0.042). Conclusions The histopathological evaluation of TLS was accurate. Diagnosis based solely on hem