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In pets provided a top sugar diet, the reaction of PAM-β'2 to sweet stimuli had been decreased and delayed, and responsive to the effectiveness of the sign transmission out from the physical neurons. We discovered that PAM-β'2 DANs activity settings feeding rate and satiation closed-loop optogenetic activation of β'2 DANs restored regular eating in animals fed high sucrose. These data argue that diet-dependent changes in taste weaken satiation by impairing the central processing of sensory signals.De
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