https://www.selleckchem.com/pr....oducts/3-deazaadenos
We synthesized conjugates of Mt-PPase with NDs and tested their activity under various conditions. Unexpectedly, conjugates of both Ec-PPase and Mt-PPase with aminated NDs retained significant hydrolytic activity in the presence of well-known mechanism-based PPase inhibitors, fluoride or calcium. The incomplete inhibition of PPases by fluoride or calcium was found for the first time. Copyright © 2020 American Chemical Society.Computer-assisted drug design (CADD) methods have greatly contributed to the development
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