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The entire population of P. squamosissimus from the Upper Paraná has been founded by a few specimens, resulting in very low genetic variability. Consequently, the population may be highly susceptible to A. compactum. Atrial high-rate episodes (AHREs) are associated with an increased risk of cerebral ischemic events; however, there are no studies related to the presence of AHREs and cerebral ischemic events in Chagasic patients. To investigate the association between the presence of AHREs ≥ 6 minutes and cerebral ischemic events in Chagas