https://www.selleckchem.com/pr....oducts/edralbrutinib
Pleomorphic dermal sarcoma (PDS) is a rare malignant cutaneous tumor with an unknown cell of origin. Locally defined tumors can be treated by curative excisions, whereas advanced stages of the disease are difficult to treat, using standard regimens. We performed whole-exome sequencing on a cohort of 28 individuals and corresponding transcriptomic analysis on 21 patients, as well as quantitative IHC image analysis on 27 patients. PDS exhibits a universally high mutational load (42.7 mutations/mega base) with an inflamed, immunogeni