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© 2020 John Wiley Sons Australian Continent, Ltd.INTRODUCTION important tremor (ET) is one of the most widespread motion disorders. The genetic etiology of ET has not been well defined although an important proportion (≥50%) are familial cases. Linkage analysis and genome-wide connection scientific studies (GWASs) have identified a few risk variations. In recent years, whole-exome sequencing of ET has revealed a few particular causal alternatives in FUS (p.Q290X), HTRA2 (p.G399S), and TENM4 (c.4324 GA, c.4100CA
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