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med stability of complexes throughout 40 ns production period.The MD simulations studies revealed the binding site flexibility, binding free energy of complexes and per-residue contribution in ligand binding.Communicated by Ramaswamy H. Sarma.Background Head and neck sarcomas are rare and difficult to diagnose and manage.Aim To describe a population of patients with head and neck sarcomas focusing on the effect of symptom duration and time to diagnosis on mortality and recurrence risk.Materials and methods Fifty-one patients tr