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Despite significant empirical support for nonabstinence alcohol interventions, there is a clear gap in research examining nonabstinence psychosocial treatment for drug use disorders. Future research must test the effectiveness of nonabstinence treatments for drug use and address barriers to implementation.Kinases are considered as important signalling enzymes that illustrate 20% of the druggable genome. Human kinase family comprises 500 protein kinases and about 20 lipid kinases. Protein kinases are responsible for the mechanism of p

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