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he treatment used, the risk of TLR was lower in BMS- versus DES-ISR (9.7% vs. 17.0%; HR 0.56; 95% CI 0.42 to 0.74), whereas safety was not significantly different between ISR types. Conclusions At 3-year follow-up, DCB angioplasty and repeat stenting with DES are similarly effective and safe in the treatment of BMS-ISR, whereas DCB angioplasty is significantly less effective than repeat DES implantation in the treatment DES-ISR, and associated with a nonsignificant reduction in the primary composite safety endpoint. Overall, DES-ISR is

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