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06±1.37 h. After oral administration (10, 20, and 50 mg/kg), protostemonine was rapidly absorbed from the gastrointestinal tract with t(max) of approximately 1 h, and has shown dose-independent pharmacokinetic behaviors. Oral bioavailability of protostemonine was calculated to be 5.87-7.38%. Moreover, a total of 10 metabolites were structurally identified by using UHPLC-Q/TOF-MS method. The proposed metabolic pathways of protostemonine in rat involve demethylation, hydrolysis, and oxygenation. The current study provides informative data