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entific basis and therapeutic mechanism of traditional Chinese medicine (TCM) formula treating for disease. To investigate the neuroprotective effect of chrysophanol (CHR) on PC12 treated with Aβ , and the involved mechanism. After the establishment of an AD cell model induced by Aβ , the cell survival rate was detected by MTT, cell apoptosis was assayed by Hoechst 33342 staining, mRNA expressions of calmodulin (CaM), calcium/calmodulin-dependent protein kinase kinase (CaMKK), calcium/calmodulin-dependent protein kinase IV (CaMKIV) and t
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