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Finally, use SubMap analysis to evaluate the response of patients in the MRPG signature group to immunotherapy. The MRGP signature can reliably predict overall survival in patients with osteosarcoma. The MRGP signature is also associated with osteosarcoma patients' metastatic status and can be used for subsequent risk classification of metastatic patients. The immunotherapy is more likely to benefit the patients in the MRGP low-risk group. Metabolic-related gene pairs signature can assess the prognosis of patients with osteosarcoma. Metabolic-related gene p

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