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The outcome suggest future use of such a system as a sensor for the analysis of in vitro as well as in vivo crowding effects on self-assembly procedures. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.Conjugation of tiny molecule drug to lipid-polymer amphiphiles is a robust strategy to alter the pharmacokinetic profile of the molecules by promoting binding to albumin or any other serum molecules. Incorporation of a responsive linker between your lipid anch