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9±10.4 to 291.6±10.9 mosm/l (p0.002), mean TBUT increased from 3.7±1.5 to 7.1±1.9s (p0.002), mean Schirmer's I test increased from 4.6±0.7 to 8.1±3.1 mm/5min (p0.03), while mean Oxford grade showed a trend towards a decrease from 2.4±0.7 to 1.3±1 (p0.1. Our trial suggests that injection of allogeneic ASCs into the LG is a safe and feasible treatment of severe ADDE. A randomized placebo-controlled trial aimed at elucidating the therapeutic effect of allogeneic ASCs in a larger patient cohort from our research group is cu