https://www.selleckchem.com/products/mk-4827.html
20 μmol/L Cur significantly decreased mRNA expression of TGF-β1, α-SMA and collagen type Ⅰ in gingival fibroblasts, and Western blot suggested significantly down-regulated expression of TGF-β1, p-Smad3, α-SMA, and collagen typeⅠ. Cur may inhibit TGF-β1/Smad3 signaling pathway of gingival fibroblasts activated by CsA, thereby weakening proliferation and migration, reducing secretion of smooth muscle actin and collagen of gingival fibroblasts, and ameliorating gingival hyperplasia. Cur may inhibit TGF-β1/Smad3 signaling pathway of gingiva
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