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To study (1) epidemiological factors, clinical profile and outcomes of COVID-19 related multisystem inflammatory syndrome in children (MIS-C), (2) clinical profile across age groups, (3) medium-term outcomes and (4) parameters associated with disease severity. Hospital-based prospective cohort study. Two tertiary care centres in Kerala, India. Diagnosed patients of MIS-C using the case definition of Centres for Disease Control and Prevention. Pearson χ test or Fisher's exact test was used to compare the categorical variables and independent s